Question

While most often associated with lung cancer, mutations in the receptor for an “epidermal” protein of this class are also linked to glioblastoma. For 10 points each:
[10m] Name these signaling proteins. Bevacizumab is the prototypic drug in a class of drugs designed to inhibit the action of one of these proteins that stimulates both normal and cancer-related angiogenesis.
ANSWER: growth factors [accept epidermal growth factor; accept vascular endothelial growth factor; prompt on EGF or VEGF by asking “what does that stand for?”]
[10h] Three answers required. Most breast cancers contain mutations that overexpress or amplify at least one of these three proteins, but “triple negative” ones do not, making them resistant to both trastuzumab and tamoxifen.
ANSWER: PR AND ER AND Her2/neu [accept answers in any order; accept progesterone receptor in place of “PR”; accept estrogen receptor in place of “ER”; accept ERBB2, NEU, CD340, c-ERB2; or erb-b2 receptor tyrosine kinase 2 in place of “Her2/neu”]
[10e] The most frequently mutated protein in human cancers is this “guardian of the genome.” This protein arrests the cell cycle at the G1/S transition if DNA damage is detected.
ANSWER: p53 [or tumor protein p53]

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Data

TeamOpponentPart 1Part 2Part 3Total
Brown ANYU A0101020
Chicago AMaryland A1001020
Chicago BImperial A1001020
Columbia ATexas A1001020
Cornell BClaremont A1001020
Florida AWUSTL A001010
Georgia Tech AMichigan A1001020
Illinois AFlorida B0000
Indiana ASouth Carolina A0000
Iowa State AJohns Hopkins A001010
Minnesota AVanderbilt A001010
Minnesota BStanford A001010
North Carolina ACornell A001010
Northwestern AGeorgia Tech B1001020
Ohio State AUC Berkeley B001010
Penn ARutgers A001010
Penn State ADuke A001010
Toronto AYale B0000
Virginia AUC Berkeley A001010
WUSTL BMcGill A001010
Yale ARutgers B1001020