Question

Every arm of the 200-megadalton molecule PG5 is terminated by one of these functional groups but protected by a Boc (“bock”). For 10 points each:
[10e] Name this functional group that is protected by Boc or Fmoc (“F-mock”) during peptide synthesis, since it is at the N-terminus of every protein.
ANSWER: amine [or amino group; or NH2 group]
[10m] Synthetic chemists prefer Boc to Fmoc because its deprotection has a higher value for this green chemistry metric. It equals the molecular weight of the desired product divided by the total molecular weight of the reactants.
ANSWER: atom economy [or atom efficiency; or atom percentage; prompt on efficiency; prompt on economy or percentage; reject “yield”]
[10h] Boc-protected peptides are cleaved off the surface using an acidic cocktail containing TIPS, which reacts as one of these nucleophiles to suck up reactive trityl (“TRY-till”) cations. In general, these species react stoichiometrically with inhibitors to prevent side reactions.
ANSWER: molecular scavengers

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Data

TeamOpponentPart 1Part 2Part 3Total
Brown ANYU A1010020
Claremont ACornell B0000
Florida AWUSTL A100010
Florida BIllinois A1010020
Georgia Tech AMichigan A100010
Imperial AChicago B0000
Indiana ASouth Carolina A100010
Johns Hopkins AIowa State A1001020
Maryland AChicago A0000
Minnesota AVanderbilt A1010020
North Carolina ACornell A1010020
Northwestern AGeorgia Tech B10101030
Ohio State AUC Berkeley B0000
Penn State ADuke A0000
Rutgers APenn A1001020
Rutgers BYale A100010
Stanford AMinnesota B1010020
Texas AColumbia A100010
Toronto AYale B100010
UC Berkeley AVirginia A1010020
WUSTL BMcGill A1010020