Question

The multi-enzyme complexes that synthesize these molecules always end with a thio·esterase module. For 10 points each:
[10h] Name these natural products that consist of alternating methyl·ene and carbonyl groups. As they’re often chemo·toxic, these molecules are popular starting points for the design of new antibiotics.
ANSWER: polyketides
[10e] Thio·esterases cleave the bond between a polyketide’s terminal acetyl group and this co·enzyme. This co·enzyme is also bound to the acetyl groups that enter the Krebs cycle.
ANSWER: coenzyme A [or CoA; or acetyl-CoA]
[10m] Thio·esterases catalyze this type of reaction during macrolide biosynthesis. Non-ribosomal peptides that have undergone this type of reaction have longer half-lives since they can only be cleaved by endo·peptidases and not exo·peptidases.
ANSWER: intramolecular cyclization [or cyclase reactions; or forming a cyclic compound; or ring formation; or ring closing]

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Data

TeamOpponentPart 1Part 2Part 3Total
Columbia BVanderbilt A010010
Cornell BColumbia A010010
Florida AChicago A010010
Georgia Tech AChicago B1010020
Georgia Tech BWUSTL B0000
Harvard AIndiana A1010020
Iowa State AMcGill A010010
MIT ANorth Carolina A0101020
Maryland AStanford A0000
Michigan AJohns Hopkins A010010
Minnesota ANorthwestern A0000
NYU AHouston A0000
Ohio State ABrown A010010
Penn AClaremont A010010
Penn State AYale B010010
Purdue AFlorida B010010
Rutgers ASouth Carolina A010010
Rutgers BImperial A010010
Toronto AChicago C010010
UC Berkeley ATexas A0101020
UC Berkeley BMinnesota B1010020
Virginia AIllinois A010010
WUSTL ADuke A010010
Yale ACornell A0101020