Question

Synthetic or viral inhibition of caspase-8 prevents extrinsic apoptosis, shifting cells to this second-line death program instead. For 10 points each:
[10h] Name this highly immunogenic form of programmed cell death mediated by RIPK3 (“rip-K-3”) and its substrate, MLKL.
ANSWER: necroptosis (“neh-crop-TOH-sis”) [accept intrinsic necroptosis or extrinsic necroptosis; prompt on regulated necrosis; reject “necrosis” or “apoptosis”]
[10e] While apoptosis shuts down cellular functions like translation that consume this molecule, those processes persist during necroptosis and contribute to the lethal decline in intracellular concentrations of this energy currency.
ANSWER: ATP [or adenosine triphosphate]
[10m] A major drain of ATP during necroptosis is hyperactivation of PARP-1 (“parp one”), an enzyme involved in this process. Other ATP-draining enzymes involved in this process in eukaryotes include MutS and MutL homologues.
ANSWER: DNA repair [accept nucleotide excision repair or NER; accept base excision repair or BER; accept mismatch repair or MMR; accept non-homologous end joining or NHEJ; accept single-stranded break repair or SSB repair; accept double-stranded break repair or DSB repair; prompt on repair; prompt on DNA damage response]

Back to bonuses

Data

TeamOpponentPart 1Part 2Part 3Total
Chicago ABrown A0101020
Chicago CColumbia A010010
Claremont AVirginia A010010
Cornell AFlorida A10101030
Cornell BHarvard A010010
Georgia Tech AWUSTL A0101020
Georgia Tech BRutgers A010010
Illinois AYale B010010
Imperial AColumbia B0101020
MIT AToronto A010010
McGill APenn A010010
Michigan APurdue A010010
Minnesota ATexas A0101020
NYU AJohns Hopkins A010010
North Carolina ANorthwestern A010010
Ohio State ADuke A001010
Penn State AWUSTL B010010
Rutgers BHouston A010010
South Carolina AIowa State A010010
Stanford AChicago B0101020
UC Berkeley AIndiana A0101020
UC Berkeley BFlorida B0101020
Vanderbilt AMinnesota B0101020
Yale AMaryland A0101020